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    HLPaper 2
    1.

    Outline the process of spermatogenesis in the human testis.

    [5]
    Verified
    Solution
    • Spermatogonia (diploid cells) undergo mitosis to produce primary spermatocytes. 1 mark
    • Primary spermatocytes undergo meiosis I to form haploid secondary spermatocytes. 1 mark
    • Secondary spermatocytes undergo meiosis II to form spermatids. 1 mark
    • Spermatids differentiate into mature sperm cells (spermatozoa). 1 mark
    • Sertoli cells provide nutrients and structural support for developing sperm. 1 mark
    • Spermatogenesis occurs in the seminiferous tubules of the testis. 1 mark
    • Testosterone stimulates sperm production in the testes. 1 mark

    Award a maximum of 5 marks.

    2.

    Compare and contrast spermatogenesis and oogenesis.

    [6]
    Verified
    Solution

    Similarities:

    • Both involve mitosis to produce precursor cells. 1 mark
    • Both involve meiosis to produce haploid gametes. 1 mark
    • Both involve cell differentiation to produce mature gametes. 1 mark Differences:
    • Spermatogenesis produces four haploid sperm per meiosis, while oogenesis produces one haploid ovum and three polar bodies. 1 mark
    • Spermatogenesis is continuous from puberty onwards, while oogenesis has long pauses (e.g., meiosis I starts before birth, meiosis II completes only at fertilization). 1 mark
    • Spermatogenesis occurs in the testes, while oogenesis occurs in the ovaries. 1 mark
    • Millions of sperm are produced daily, whereas only one egg is released per menstrual cycle. 1 mark

    Award a maximum of 6 marks: 3 marks for discussing similarities, and 3 marks for discussing differences

    3.

    Discuss the roles of the placenta during pregnancy.

    [8]
    Verified
    Solution
    • The placenta facilitates the exchange of nutrients (e.g., glucose, amino acids) from the mother's blood to the fetus. 1 mark
    • It allows for the exchange of waste products (e.g., carbon dioxide and urea) from the fetus to the mother. 1 mark
    • The placenta produces hormones, including human chorionic gonadotropin (hCG), which maintains the corpus luteum and progesterone production. 1 mark
    • Later in pregnancy, the placenta secretes progesterone and estrogen to maintain the uterine lining and prevent contractions. 1 mark
    • It acts as a barrier to some pathogens (though not all, e.g., some viruses like rubella can cross the placenta). 1 mark
    • It provides oxygen to the fetus via diffusion. 1 mark
    • It has chorionic villi to increase surface area for efficient exchange of substances. 1 mark
    • The placenta prevents maternal and fetal blood from mixing, which is important due to possible differences in blood types. 1 mark
    • The umbilical cord connects the fetus to the placenta, containing two arteries and one vein to facilitate blood transport. 1 mark

    Award a maximum of 8 marks.

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