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    HLPaper 2
    1.

    Outline four types of membrane transport, including their use of energy.

    [4]
    Verified
    Solution

    a. simple diffusion is passive movement of molecules/ions along a concentration gradient ✓ b. facilitated diffusion is passive movement of molecules/ions along a concentration gradient through a protein channel «without use of energy» ✓ c. osmosis is the passage of water through a membrane from lower solute concentration to higher ✓ d. active transport is movement of molecules/ions against the concentration gradient «through membrane pumps» with the use of ATP/energy ✓ e. endocytosis is the infolding of membrane/formation of vesicles to bring molecules into cell with use of energy OR exocytosis is the infolding of membrane/formation of vesicles to release molecules from cell with use of energy ✓ f. chemiosmosis occurs when protons diffuse through ATP synthase «in membrane» to produce ATP ✓

    2.

    Draw the structure of a dipeptide.

    [2]
    Verified
    Solution

    a. two amino acids, one with NH2NH_2NH2​/NH3+NH_3^+NH3+​ end and one with COOHCOOHCOOH/COO−COO^-COO− end ✓ b. peptide bond between C=OC=OC=O and N−HN-HN−H correctly drawn ✓ c. «chiral» C with H and R group on each amino acid ✓ d. peptide bond labelled/clearly indicated between C terminal of one amino acid and N terminal of the second amino acid ✓

    3.

    ADH (antidiuretic hormone) is a peptide hormone that is produced in the hypothalamus. Explain its action in the human body.

    [6]
    Verified
    Solution

    a. ADH plays a role in osmoregulation/regulating blood solute concentration ✓ b. acts on the collecting ducts of the kidney ✓ c. acts in «late» distal convoluted tubule ✓ d. hypothalamus detects plasma/blood osmolarity/solute concentration ✓ e. if plasma/blood is too concentrated/hypertonic, «posterior» pituitary releases ADH ✓ f. ADH stimulates insertion of aquaporins/water channels / increases permeability of collecting duct ✓ g. water moves «through aquaporins» by osmosis into the medulla/blood ✓ h. urine becomes more concentrated/smaller volume ✓ i. negative feedback occurs ✓ j. if blood is hypotonic no ADH is released ✓ k. water is not reabsorbed from the collecting ducts/permeability of the collecting duct decreases ✓ l. urine becomes more dilute/less concentrated / higher volume ✓

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