Release and Reuptake of Tissue Fluid: A Pressure Balance Along the CapillaryDefinitionTissue fluidFluid found in the spaces around cellsTissue fluid, also called interstitial fluid, is the fluid that surrounds cells in tissues, formed from plasma that leaves the capillaries.Common MistakeTissue fluid is not identical to blood plasma.It comes from plasma but lacks the large plasma proteins and blood cells, which stay inside the capillary.Formation at the Arterial End: High Blood Pressure Filters Fluid OutBlood enters the capillaries from the arterioles under high pressure.At the arterial end, the hydrostatic (blood) pressure is greater than the osmotic pull of the plasma proteins.This net outward pressure forces plasma out through the permeable capillary wall to form tissue fluid.This filtering of fluid under pressure is called pressure filtration (ultrafiltration).The large plasma proteins and blood cells are too big to pass through, so they stay in the capillary.