Recognizing Monosaccharides: Pentoses vs. Hexoses
- Basic Building Blocks
- Monosaccharides are the simplest form of carbohydrates.
- They provide the foundation for more complex carbohydrates (disaccharides, polysaccharides).
- Pentoses (5-Carbon Sugars)
- Ribose (C₅H₁₀O₅) and Deoxyribose (C₅H₁₀O₄).
- Crucial components of RNA (ribose) and DNA (deoxyribose).
- Form the sugar-phosphate backbone in nucleotides.
- Hexoses (6-Carbon Sugars)
- Example: Glucose (C₆H₁₂O₆).
- Often found in ring forms, which are more stable and biologically active.
Here is a helpful memory:
"Pentagons Have Hexagons, Both Ring Stable"
- Pentagons = Pentoses (5 carbon atoms, e.g., ribose, deoxyribose)
- Have = Hexoses (6 carbon atoms, e.g., glucose)
- Hexagons = Ring forms (more stable than straight chains)
- Both = Both pentoses and hexoses exist in ring form
- Ring Stable = Ring form is more biologically functional
The Ring Structure of Glucose (A Hexose)
- Glucose (C₆H₁₂O₆) is a hexose with 6 atoms in its ring: 5 carbon atoms and 1 oxygen atom.
- Glucose has two forms:
- α-glucose
- β-glucose
3. They differ in the orientation of the hydroxyl group attached to carbon 1.

Pentoses: Ribose and Deoxyribose
- Ribose (C₅H₁₀O₅) and Deoxyribose (C₅H₁₀O₄) are pentoses.
- Ribose is part of the structure of RNA, and Deoxyribose is part of DNA.
- These sugars form the backbone of nucleotides in genetic material.
Pentoses like ribose and deoxyribose are critical for genetic information storage, while hexoses such as glucose are primarily energy sources.
Properties of Glucose and Their Biological Significance
- Glucose is highly important in living organisms. Its properties make it perfect for energy transport and storage.
Solubility
- Glucose is soluble in water because it has hydroxyl (–OH) groups, forming hydrogen bonds with water.
- This allows glucose to dissolve in the blood and be transported to cells.
- Imagine stirring a sugar cube into water.
- Like the sugar cube, glucose dissolves easily, ensuring it can travel through the bloodstream to deliver energy wherever it’s needed.


