D3.3.3 Regulation of blood glucose as an example of the role of hormones in homeostasis
D3.3.3 Regulation of blood glucose as an example of the role of hormones in homeostasis Notes
Blood Glucose Regulation: Insulin and Glucagon Maintain Balance
Blood glucose levels must be carefully regulated to maintain homeostasis.
Two hormones, insulin and glucagon, work in opposition to keep blood glucose levels within a narrow, healthy range.
These hormones are produced by the pancreas and act on target cells throughout the body.
Insulin and glucagon as a negative feedback loop
The Pancreas Detects and Responds to Glucose Changes
The pancreas serves as both a sensor and responder in regulating blood glucose.
Dual Function of the Pancreas:
Exocrine Function: Produces digestive enzymes to aid in digestion.
Endocrine Function: Contains islets of Langerhans, which house two types of cells:
Alpha Cells: which secrete glucagon to increase blood glucose.
Beta Cells: which secrete insulin to decrease blood glucose.
Negative Feedback Loop Maintains Balance
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Questions
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Question 1
Recap question
A constitutively active mutation in glucagon receptors in hepatocytes causes receptor signaling even in the absence of glucagon. After an overnight fast, which pattern of blood-glucose level and hormone concentrations would you most likely observe?
What happens to glucose in the liver and muscles when insulin is released?
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Note
The human body maintains a stable internal environment through a process called homeostasis. One crucial aspect of homeostasis is regulating blood glucose levels, which provide energy for our cells.
Homeostasis is like a thermostat that keeps your house at a constant temperature, adjusting heating or cooling as needed.
Blood glucose levels are tightly controlled between 4-6 mmol/L (millimoles per liter) in healthy individuals.
Glucose is the primary energy source for our cells, especially the brain.
AnalogyThink of blood glucose regulation like a car's cruise control system, which adjusts the throttle to maintain a constant speed.
DefinitionHomeostasisThe maintenance of a stable internal environment within narrow limits despite external changes.
DefinitionBlood Glucose LevelsThe concentration of glucose in the blood, measured in mmol/L.