IB Biology Topic C2.1.12 Intracellular Receptors That Affect Gene Expression Revision Notes (HL)

IB Biology Topic C2.1.12 Intracellular Receptors That Affect Gene Expression Revision Notes (HL) | RevisionDojo

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Lipophilic Signals Enter the Cell and Switch Genes On or Off

Some signalling molecules, such as steroid hormones and thyroid hormone, are lipophilic and diffuse straight across the plasma membrane.
Inside the cell they bind intracellular receptors in the cytoplasm or nucleus.
The hormone-receptor complex acts as a transcription factor, binding specific DNA sequences to change which genes are switched on or off.

Note

Water-soluble signals cannot cross the membrane and instead use transmembrane receptors, covered in C2.1.6 and C2.1.8 to C2.1.11.

The Mechanism Runs From Diffusion to Transcription in Four Steps

Being lipophilic, the signal diffuses through the plasma membrane into the cell.

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Lipophilic Signals Enter the Cell and Switch Genes On or Off

Some signalling molecules, such as steroid hormones and thyroid hormone, are lipophilic and diffuse straight across the plasma membrane.
Inside the cell they bind intracellular receptors in the cytoplasm or nucleus.
The hormone-receptor complex acts as a transcription factor, binding specific DNA sequences to change which genes are switched on or off.

Note

Water-soluble signals cannot cross the membrane and instead use transmembrane receptors, covered in C2.1.6 and C2.1.8 to C2.1.11.

The Mechanism Runs From Diffusion to Transcription in Four Steps

Being lipophilic, the signal diffuses through the plasma membrane into the cell.

Definition

Paywall

(on a website) an arrangement whereby access is restricted to users who have paid to subscribe to the site.

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Note

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam quis nostrud exercitation.

Excepteur sint occaecat cupidatat non proident

Tip

Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris.
Duis aute irure dolor in reprehenderit in voluptate velit esse cillum.

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A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

IB Biology Topic C2.1.12: Intracellular Receptors That Affect Gene Expression Notes

A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

Lipophilic Signals Enter the Cell and Switch Genes On or Off

The Mechanism Runs From Diffusion to Transcription in Four Steps

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account

Lipophilic Signals Enter the Cell and Switch Genes On or Off

The Mechanism Runs From Diffusion to Transcription in Four Steps

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account