A1.2.6 DNA as a double helix linked by hydrogen bonding between complementary base pairs
A1.2.6 DNA as a double helix linked by hydrogen bonding between complementary base pairs Notes
DNA Consists Of Two Polynucleotide Strands
Each strand has a sugar–phosphate backbone with nitrogenous bases projecting inward.
The strands align side by side, forming a double-stranded structure.
The Antiparallel Arrangement of DNA Strands
The two DNA strands run in opposite directions.
One strand runs 5′ to 3′, while the other runs 3′ to 5′.
This arrangement is called antiparallel.
Drawing the Structure of DNA
When drawing DNA, show:
Antiparallel strands: One labeled 5' to 3' and the other 3' to 5'.
Complementary base pairing: Show A paired with T and C paired with G, connected by hydrogen bonds.
Sugar-phosphate backbone: Represent the backbone as a continuous chain of alternating sugar and phosphate groups.
You are not required to draw the helical shape of DNA.
Theory of Knowledge
Complementary base pairing is universal across all living organisms.
How does this reflect the shared evolutionary ancestry of life?
Consider how the universality of DNA connects to the Theory of Knowledge.
Self review
What does it mean that DNA strands are antiparallel, and how is this shown in diagrams?
Which bases pair together in DNA, and what bonds hold them together?
Why is complementary base pairing essential for DNA replication?
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Note
DNA as a Double Helix
DNA is a double helix, meaning it consists of two intertwined strands that form a spiral structure.
The two strands are held together by hydrogen bonds between specific pairs of nitrogenous bases.
This structure was first discovered by Watson and Crick in 1953.
AnalogyThink of the DNA double helix like a twisted ladder, where the sugar-phosphate backbones are the sides of the ladder and the base pairs are the rungs.