Bases in Nucleic Acids That Form the Basis of a Code
DNA and RNA store genetic information using nitrogenous bases that form the basis of the genetic code.
The sequence of these bases encodes instructions for building proteins.
The Four Nitrogenous Bases of DNA
DNA contains four nitrogenous bases:
Adenine (A)
Thymine (T)
Cytosine (C)
Guanine (G)
The Four Nitrogenous Bases in RNA
While RNA shares three of its bases with DNA, there is one important difference:
Adenine (A)
Uracil (U) (replaces Thymine in RNA)
Cytosine (C)
Guanine (G)
Self review
Which four bases are present in DNA, and which four are present in RNA?
Which base in RNA replaces thymine, and how does this affect transcription?
Which bases are purines, and which are pyrimidines?
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What are the two categories of nitrogenous bases in nucleic acids?
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DNA and RNA store genetic information using nitrogenous bases. The order (sequence) of bases acts like a code that can be read to make proteins.
In other words, what matters most is the sequence of bases along the nucleic acid strand, because that sequence is what cells interpret during gene expression.
Definitionnitrogenous baseA nitrogen-containing chemical “letter” in DNA/RNA. The sequence of bases stores information.
These bases are the information-bearing parts of nucleotides, and their sequence is what can be copied and read.
Analogy
Think of bases like letters in a message: changing the order changes the meaning.
Even if you have the same set of letters, rearranging them can create a completely different message—similarly, changing base order can change the protein that gets made.
Note
The “genetic code” is information stored in the base sequence, not in the sugar or phosphate parts of nucleic acids.
The sugar-phosphate backbone mainly provides structure and stability, while the base sequence carries the instructions.