Water-soluble signals stay outside and use surface receptors; lipid-soluble signals pass through and use internal receptors.
Receptor
A receptor is a protein that detects and responds to specific signals. They bind to signalling molecules(ligands) to initiate a cellular response.
Transmembrane receptors
Transmembrane receptors are embedded in the plasma membrane and interact with signalling molecules that cannot cross the membrane.
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Paywall
(on a website) an arrangement whereby access is restricted to users who have paid to subscribe to the site.
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