IB Biology Topic C1.1.7: The Structure of the Active Site, Enzyme–substrate Specificity and Denaturation Notes

The Active Site Is a Precise Pocket Built by Protein Folding

Definition

Active site

The active site is a small region on an enzyme where the substrate binds. It is formed by a specific sequence of amino acids within the enzyme's overall three-dimensional structure.

The active site is a small region on the enzyme where the substrate binds.

Its shape and chemistry are set by the enzyme's amino acid sequence and the way the protein folds.

What Makes the Active Site Specific

Shape complementarity

The active site's shape matches the substrate, so only that substrate fits.

Chemical compatibility

The amino acids lining the site have charges and other properties that match the substrate.

Tip

Only a few amino acids in the active site take part directly in catalysis.
Folding brings these amino acids together even when they sit far apart in the sequence.

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Note

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Tip

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Definition

Paywall

(on a website) an arrangement whereby access is restricted to users who have paid to subscribe to the site.

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Note

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam quis nostrud exercitation.

Excepteur sint occaecat cupidatat non proident

Tip

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Sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris.
Duis aute irure dolor in reprehenderit in voluptate velit esse cillum.

IB Biology Topic C1.1.7: The Structure of the Active Site, Enzyme–substrate Specificity and Denaturation Notes

Each Enzyme's Active Site Fits One Substrate, So It Catalyses One Reaction

The Active Site Is a Precise Pocket Built by Protein Folding

What Makes the Active Site Specific

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account

Each Enzyme's Active Site Fits One Substrate, So It Catalyses One Reaction

The Active Site Is a Precise Pocket Built by Protein Folding

What Makes the Active Site Specific

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

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A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

IB Biology Topic C1.1.7: The Structure of the Active Site, Enzyme–substrate Specificity and Denaturation Notes

Each Enzyme's Active Site Fits One Substrate, So It Catalyses One Reaction

The Active Site Is a Precise Pocket Built by Protein Folding

What Makes the Active Site Specific

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account

Each Enzyme's Active Site Fits One Substrate, So It Catalyses One Reaction

The Active Site Is a Precise Pocket Built by Protein Folding

What Makes the Active Site Specific

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account

A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics