IB Biology Topic C1.1.17 Mechanism-based Inhibition Revision Notes (HL)

IB Biology Topic C1.1.17 Mechanism-based Inhibition Revision Notes (HL) | RevisionDojo

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Mechanism-Based Inhibition: Permanently Disabling an Enzyme

Definition

Mechanism-based inhibition

Mechanism-based inhibition, also called suicide inhibition, occurs when an inhibitor binds irreversibly to the active site of an enzyme and causes chemical changes that permanently deactivate the enzyme

A mechanism-based inhibitor permanently shuts down an enzyme by exploiting the enzyme's own catalytic mechanism.
Unlike reversible inhibitors, which only block the enzyme temporarily, it forms a covalent bond and disables the enzyme irreversibly.
The inhibitor first binds to the active site, mimicking the enzyme's normal substrate.
The enzyme starts to act on it, and this reaction forms a covalent bond with the enzyme.
This locks the inhibitor in place and inactivates the enzyme for good.

Note

This is also called suicide inhibition, because the enzyme destroys its own activity by acting on the inhibitor.

Penicillin: A Classic Mechanism-Based Inhibitor

Penicillin kills bacteria by irreversibly inhibiting the enzyme DD-transpeptidase, also known as a penicillin-binding protein.
Bacterial cell walls are made of peptidoglycan, a mesh that gives the wall strength and stops the cell bursting.

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Definition

Paywall

(on a website) an arrangement whereby access is restricted to users who have paid to subscribe to the site.

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Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.

Duis aute irure dolor in reprehenderit

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Note

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam quis nostrud exercitation.

Excepteur sint occaecat cupidatat non proident

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Tip

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.

Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris.
Duis aute irure dolor in reprehenderit in voluptate velit esse cillum.

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Mechanism-Based Inhibition: Permanently Disabling an Enzyme

Definition

Mechanism-based inhibition

A mechanism-based inhibitor permanently shuts down an enzyme by exploiting the enzyme's own catalytic mechanism.
Unlike reversible inhibitors, which only block the enzyme temporarily, it forms a covalent bond and disables the enzyme irreversibly.
The inhibitor first binds to the active site, mimicking the enzyme's normal substrate.
The enzyme starts to act on it, and this reaction forms a covalent bond with the enzyme.
This locks the inhibitor in place and inactivates the enzyme for good.

Note

This is also called suicide inhibition, because the enzyme destroys its own activity by acting on the inhibitor.

Penicillin: A Classic Mechanism-Based Inhibitor

Penicillin kills bacteria by irreversibly inhibiting the enzyme DD-transpeptidase, also known as a penicillin-binding protein.
Bacterial cell walls are made of peptidoglycan, a mesh that gives the wall strength and stops the cell bursting.

Definition

Paywall

(on a website) an arrangement whereby access is restricted to users who have paid to subscribe to the site.

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Note

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam quis nostrud exercitation.

Excepteur sint occaecat cupidatat non proident

Tip

Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris.
Duis aute irure dolor in reprehenderit in voluptate velit esse cillum.

A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

IB Biology Topic C1.1.17: Mechanism-based Inhibition Notes

A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

Mechanism-Based Inhibition: Permanently Disabling an Enzyme

Penicillin: A Classic Mechanism-Based Inhibitor

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account

Mechanism-Based Inhibition: Permanently Disabling an Enzyme

Penicillin: A Classic Mechanism-Based Inhibitor

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

Unlock the rest of this chapter with a free account