Surface Area-to-Volume Ratios Constrain Cell Size
- Cells need to exchange materials such as nutrients, waste products, and gases (like oxygen and carbon dioxide) through their cell membrane.
- The surface area (SA) determines the available space through which these exchanges can occur, while the volume (V) determines how much material needs to be exchanged.
Why This Ratio Matters
- Surface Area: Larger surface area allows for more material to be transported into or out of the cell.
- Volume: The cell’s internal volume dictates how much material (like nutrients or waste) needs to be exchanged.
- As a cell increases in size, its volume increases faster than its surface area, leading to a lower surface-area-to-volume ratio.
- This means that larger cells have a harder time exchanging materials efficiently, as the surface area available for exchange does not grow as quickly as the volume needing exchange.
Mathematical Formula for Surface Area and Volume
- Surface Area (SA) of a Cube = 6 × (side length)²
This is because a cube has six square faces, and each face’s area is given by the square of its side length. - Volume (V) of a Cube = (side length)³
The volume is determined by the cube’s side length raised to the power of three.
Surface Area-to-Volume Ratio:
SA:V Ratio = Surface Area / Volume
= 6 × (side length)² / (side length)³
= 6 / side length
Examples of the Surface Area-to-Volume Ratio
Example 1: Small Cube (Side length = 1 unit)
- Surface Area = 6 × (1)² = 6 units²
- Volume = (1)³ = 1 unit³
- SA:V Ratio = 6 / 1 = 6
Example 2: Medium Cube (Side length = 2 units)
- Surface Area = 6 × (2)² = 24 units²
- Volume = (2)³ = 8 units³
- SA:V Ratio = 24 / 8 = 3
Example 3: Large Cube (Side length = 3 units)
- Surface Area = 6 × (3)² = 54 units²
- Volume = (3)³ = 27 units³
- SA:V Ratio = 54 / 27 = 2

- As the side length of the cube increases, the surface area-to-volume ratio decreases.
- Larger cells (with a lower SA:V ratio) have less surface area available for material exchange relative to their internal volume, leading to slower or less efficient transport of materials across the cell membrane.
Lab Activity: Jelly Cube Experiment
One effective way to understand surface area-to-volume ratios is by conducting an experiment with jelly cubes. This experiment demonstrates how the size of a cell can affect the rate of diffusion and material exchange.
Activity: Jelly Cube Diffusion
Objective: To visualize how the surface area-to-volume ratio affects the efficiency of diffusion in a cell.
Materials:
- Agar jelly (with a color indicator, such as phenolphthalein, for clear observation)
- Sodium hydroxide (NaOH) solution
- Ruler


