IB Biology Topic D1.2.15: Post-transcriptional Modification in Eukaryotic Cells Notes

Post-transcriptional modification turns pre-mRNA into mature mRNA in eukaryotic cells

In eukaryotes, the initial transcript called pre-mRNA is modified in the nucleus before it becomes mature mRNA.

Three modifications make the mRNA stable, accurate, and ready for export to the cytoplasm for translation.

Note

Post-transcriptional modification is unique to eukaryotes, because their transcription and translation are separated by the nuclear envelope.

The three modifications each protect and prepare the transcript

Removal of introns and splicing of exons builds a continuous coding sequence.

Eukaryotic genes contain exons (coding regions) interrupted by introns (non-coding regions).
The spliceosome removes the introns from the pre-mRNA.
The remaining exons are spliced together so the mature mRNA carries only coding regions.

Addition of a 5' cap attaches a modified guanine nucleotide to the 5' end of the transcript.

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IB Biology Topic D1.2.15: Post-transcriptional Modification in Eukaryotic Cells Notes

Post-transcriptional modification turns pre-mRNA into mature mRNA in eukaryotic cells

The three modifications each protect and prepare the transcript

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

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Post-transcriptional modification turns pre-mRNA into mature mRNA in eukaryotic cells

The three modifications each protect and prepare the transcript

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

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A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

IB Biology Topic D1.2.15: Post-transcriptional Modification in Eukaryotic Cells Notes

A - Unity and Diversity9 subtopics

B - Form and Function10 subtopics

C - Interaction and Interdependence9 subtopics

D - Continuity and Change12 subtopics

Post-transcriptional modification turns pre-mRNA into mature mRNA in eukaryotic cells

The three modifications each protect and prepare the transcript

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

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Post-transcriptional modification turns pre-mRNA into mature mRNA in eukaryotic cells

The three modifications each protect and prepare the transcript

anim nostrud sit dolore minim proident quis fugiat velit et eiusmod nulla quis nulla mollit dolor sunt culpa aliqua

Duis aute irure dolor in reprehenderit

Excepteur sint occaecat cupidatat non proident

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